Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence
نویسندگان
چکیده
منابع مشابه
Imaging tuberculosis with endogenous beta-lactamase reporter enzyme fluorescence in live mice.
The slow growth rate and genetic intractability of tubercle bacilli has hindered progress toward understanding tuberculosis, one of the most frequent causes of death worldwide. We overcame this roadblock through development of near-infrared (NIR) fluorogenic substrates for beta-lactamase, an enzyme expressed by tubercle bacilli, but not by their eukaryotic hosts, to allow real-time imaging of p...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2019
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.01462-19